How does the Wegovy pill help with weight loss?

Quick answer: The Wegovy tablet contains the active ingredient semaglutide, a GLP-1 receptor agonist. Semaglutide mimics the body’s own gut hormone, GLP-1. This increases the feeling of fullness, reduces cravings and hunger, and slightly slows down gastric emptying. As a result, you eat less, which can contribute to weight loss. The Wegovy tablet is an alternative to the injections.

In brief

• Active ingredient: semaglutide, a GLP-1 receptor agonist.
• Form: tablet (taken orally), once a day, no injection.
• How it works: increased feeling of fullness, reduced hunger, delayed gastric emptying.
• Clinical trial results: an average weight loss of 14% after 64 weeks at a dose of 25 mg.
• Availability: available on prescription only, following an initial consultation and assessment by a doctor.

What is the Wegovy tablet (semaglutide in tablet form)?

The Wegovy tablet is a prescription-only weight-loss medicine containing the active ingredient semaglutide in tablet form. Semaglutide is a GLP-1 receptor agonist: a substance that mimics the action of the gut hormone GLP-1 (glucagon-like peptide-1). This hormone plays a role in appetite, digestion and blood sugar regulation. [1]

Semaglutide is also known from the Wegovy injection. The difference between the tablet and the injection is the method of administration: the Wegovy tablet is taken daily, whilst the injectable versions (such as the Wegovy injection and Mounjaro) are administered weekly. For people who are apprehensive about needles, the tablet may help overcome this barrier.

Important: The Wegovy tablet is available on prescription only. At Goodweigh, you first complete an online assessment; a registered doctor will assess whether the treatment is suitable for you and medically justified.

How does the Wegovy pill work in the body? (mechanism of action)

Semaglutide binds to the GLP-1 receptor and activates it. As the substance is protected against rapid breakdown by enzymes, semaglutide remains active in the body for a long time. It works via two main pathways: [1]

1. In the brain: semaglutide affects the areas that regulate hunger and satiety. This increases the feeling of fullness and reduces cravings and hunger. It also reduces the preference for high-fat foods.
2. In the stomach and pancreas: semaglutide slightly slows down gastric emptying shortly after a meal, making you feel fuller for longer. It also stimulates the release of insulin when blood sugar levels are elevated.

Effect on appetite and blood sugar

Reduced hunger, feeling full more quickly and slower gastric emptying. This is the combined effect, which ensures that most users naturally eat smaller portions and feel less need to snack between meals. This is the mechanism by which semaglutide can support weight loss.

How quickly does the Wegovy tablet work?

The appetite-suppressing effect may be noticeable as early as the first few weeks. However, the effect on body weight develops gradually, over several months, as the dose is increased in stages. In clinical trials, the average weight loss was measured after 64 weeks of treatment. [3]

How do you take the Wegovy tablet? (dose escalation and administration)

The dose of oral semaglutide is increased gradually to minimise gastrointestinal side effects. The schedule below shows the usual dose escalation; your doctor will determine the final dose and the rate of increase. [3]

Directions for use: Take the tablet once a day in the morning on an empty stomach, with no more than half a glass of water. Wait at least 30 minutes before eating, drinking or taking any other medicines. Always refer to the official patient information leaflet and your doctor’s instructions.

How much weight can you lose with the Wegovy pill?

In a clinical trial involving 307 adults with obesity (or overweight with a weight-related condition), participants taking 25 mg of oral semaglutide lost an average of 14% of their body weight after 64 weeks, in combination with lifestyle advice. The placebo group lost an average of 2.4%. Of the participants, 28% achieved a weight loss of 20% or more, compared with 3% in the placebo group. [3]

Calculation example: with a starting weight of 100 kg, 14% amounts to approximately 14 kg. Individual results may vary significantly.

Can I lose 10 kg with the Wegovy pill?

Straight answer: For many users, 10 kg is a realistic goal, but whether you achieve it depends mainly on your starting weight, the dosage and your lifestyle. In clinical trials, users of 25 mg oral semaglutide lost an average of 14 per cent of their body weight after 64 weeks. [3]

Calculation example: 10 kg corresponds to approximately 14% of 71 kg. If you weigh more than this, losing 10 kg is generally within reach; with a lower starting weight, losing 10 kg is proportionally a greater challenge.

14% is an average: some people lose more weight, others less. The best results are achieved in combination with a tailored diet, increased physical activity and a gradual, steady increase in dosage. Individual results may vary significantly.

Who is the Wegovy pill suitable for (and who is it not suitable for)?

The Wegovy pill is generally considered for adults with: [2]

• a BMI of 30 or higher (obesity), or
• a BMI of 27 or higher in combination with a weight-related condition (e.g. type 2 diabetes, high blood pressure, high cholesterol).

The Wegovy pill is not suitable (or only after medical consultation) for, amongst others:

• a healthy weight; the Wegovy pill is not intended for cosmetic weight loss;
• pregnancy, breastfeeding or actively trying to conceive;
• a history of medullary thyroid carcinoma (MTC) or MEN 2;
• a previous episode of pancreatitis;
• people under the age of 18.

What are the side effects of the Wegovy pill?

Immediate answer: The most common side effects of the Wegovy pill (semaglutide) are gastrointestinal symptoms such as nausea and diarrhoea. These are usually mild and temporary and occur mainly whilst the dose is being titrated. Serious side effects are rare, but do require immediate medical attention. [1]

In brief

• Most common: nausea and diarrhoea.
• Usually mild and temporary, particularly when the dose is being increased.
• Serious side effects (such as pancreatitis) are rare.
• A gradual increase in dosage reduces the risk of side effects.
• Unsure or experiencing persistent symptoms? Contact your doctor.

Side effects by frequency

The overview below is based on the official product information for semaglutide. The frequencies indicate how often a side effect occurs on average. [1]

This list is not exhaustive. Always refer to the official patient information leaflet for a complete overview. [4]

How long do the side effects of the Wegovy tablet last?

Most gastrointestinal symptoms occur during the first few weeks and whenever the dose is increased. For most people, the symptoms subside once the body has become accustomed to the medicine. This is precisely why the dose is increased gradually: a gradual build-up reduces the likelihood and severity of side effects. [1]

Checklist: managing the side effects of the Wegovy pill

The advice below can help to reduce symptoms. It is intended as a guide and does not replace medical advice; if symptoms persist, always consult your doctor. [2]

General advice (for all symptoms)

• Eat smaller portions spread throughout the day and stop when you feel full.
• Eat slowly and chew your food thoroughly.
• Avoid large, fatty or heavy meals.
• Stay sitting upright for a while after eating; do not lie down straight away.
• Drink plenty of water, spread throughout the day; do not drink large amounts at once with a meal.
• Ensure you get enough protein and pay attention to your fibre intake.
• Limit alcohol if it makes your symptoms worse.
• Follow your doctor’s titration schedule and do not increase the dose yourself.

For nausea

• Choose light, simple meals.
• Avoid fried or fatty foods and strong smells.
• Drink small sips of water throughout the day.
• Some people find ginger or peppermint tea helpful (as a supportive measure, not a treatment).

For constipation

• Make sure you drink plenty of water consistently.
• Gradually increase your fibre intake with vegetables, fruit, whole grains and pulses.
• Get some exercise every day, such as going for a walk.
• Don’t restrict your diet too much.

For diarrhoea

• Stay hydrated.
• Temporarily avoid fatty, heavy or strongly spiced foods.
• Be aware of possible triggers such as coffee, alcohol and sweeteners.
• Eat smaller portions and choose foods that are easy to digest.

For heartburn or acid reflux

• Eat smaller, less fatty meals.
• Do not lie down immediately after eating; if necessary, raise the head of your bed.
• Limit coffee, alcohol and spicy food if these cause symptoms.
• Consult your pharmacist or doctor before taking antacids yourself.

If you experience tiredness, headaches or dizziness

• Make sure you eat enough of the foods you can tolerate and drink plenty of fluids.
• Ensure you get enough protein and rest.
• Contact your doctor if you have severe or persistent symptoms, particularly if you have diabetes (blood sugar).

When should you contact a doctor whilst taking the Wegovy pill?

Contact your doctor if you experience: [1]

• persistent or worsening side effects;
• nausea or vomiting that prevents you from eating or drinking enough;
• persistent constipation or diarrhoea;
• signs of dehydration (dark urine, infrequent urination, severe dizziness);
• new or unexplained symptoms.

Call 112 immediately or seek emergency medical assistance if you experience: [1]

• severe, persistent abdominal pain, especially if it radiates to the back (possible pancreatitis);
• repeated or severe vomiting, or blood in vomit or stools;
• yellowing of the skin or eyes, or dark urine with pale stools;
• sudden loss of vision or rapidly deteriorating vision;
• swelling of the face, lips, tongue or throat, shortness of breath or difficulty swallowing;
• chest pain, severe palpitations, fainting or confusion.

If in doubt, it is better to contact a doctor too soon than too late.

For whom do these side effects require extra attention?

Extra caution (or use only after consulting a doctor) is advised, amongst other things, in the following cases: [2]

• a history of pancreatitis;
• gallstones or gallbladder problems;
• kidney problems; dehydration caused by gastrointestinal symptoms can put extra strain on the kidneys;
• use of insulin or certain diabetes medication; increased risk of low blood sugar;
• pregnancy, breastfeeding or planning to conceive; semaglutide is not recommended in these cases.

During the initial consultation, your doctor will assess whether the Wegovy tablet is safe for you.

What is the best diet to follow whilst taking the Wegovy tablet?

Quick answer: When taking the Wegovy tablet, a high-protein, high-fibre diet with smaller portions works best. This supports weight loss, helps maintain muscle mass and minimises gastrointestinal symptoms. [2]

What you should eat

• Plenty of protein (low-fat dairy, eggs, chicken, fish, pulses) to maintain muscle mass.
• Fibre-rich foods (vegetables, fruit, whole grains, pulses) for good digestion.
• Smaller portions, spread throughout the day; stop when you feel full.
• Plenty of water, spread throughout the day.

What you should limit

• Large, fatty or fried meals; these increase the risk of nausea.
• High sugar content and highly processed foods.
• Alcohol, especially if it causes symptoms.

As your appetite decreases, there is a risk that you may not be getting enough protein and nutrients. Be mindful of this. This is general information and not personalised dietary advice; if in doubt, consult your doctor or a dietitian.

How much does the Wegovy pill cost?

The price includes an online assessment, a doctor’s evaluation and discreet home delivery. You pay per monthly pack; the price may increase as the dosage rises.

No subscription or commitments – you order on a per-treatment basis. For weight loss, semaglutide is not usually covered by health insurance.

What is the difference between the Wegovy pill and other weight-loss medicines?

The percentages reflect the average weight loss from clinical trials (depending on dosage and duration of the study), with the source cited.

The percentages refer to the average weight loss observed in clinical trials and vary depending on the dose and duration of the study. Discuss with your doctor which treatment is suitable for your situation.

Is the weight loss maintained after stopping treatment?

Semaglutide supports weight loss as long as it is used in combination with lifestyle changes. Research shows that some of the weight lost may be regained after treatment is stopped. Long-term results therefore require a focus on diet, exercise and behaviour, even in the longer term.

The Wegovy pill is not yet available

The Wegovy pill is not currently available at Goodweigh. Would you like to be the first to know when the treatment becomes available? Sign up for the waiting list

Are you wondering whether you’re already eligible for another weight-loss treatment at Goodweigh? View the treatments and complete the intake form